Two Horn Unicorn
S.E.M.I.: Side Effects May Include...
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.
- Released
- 23 January 2026
- Developer
- Two Horn Unicorn
- Publisher
- Two Horn Unicorn
- Engine
- Unreal Engine 5
- Controller
- Full controller support
- Platforms
- PC (Microsoft Windows)
- Genres
- Hack and slash/Beat 'em up · Indie · Arcade
- 9
- Achievements
- 3
- DLC packs
S.E.M.I.: Side Effects May Include...
Quick answers
S.E.M.I.: Side Effects May Include...
The story
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.
Browse
Key facts
Platforms
Game modes
- Single player
- Multiplayer
- Co-operative
Themes
- Action
- Comedy
- Party
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Screenshots
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Reviews and languages
9 languages in the interface, 0 of them with full voice acting. English is supported.
S.E.M.I.: Side Effects May Include...
